Wissen schafft Zukunft.

  Klinik und Poliklinik
  für RadioOnkologie
  und Strahlentherapie

  Klinikleitung
  Univ.-Prof. Dr. med.
  Stephanie E. Combs

  Klinikum rechts der Isar
  Technische Universität München
  Ismaninger Str. 22
  D - 81675 München
  direktion.radonk@mri.tum.de

 

GLIAA Studie

Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme - a randomised phase II trial

This study is designed to test if a radiotherapy target volume delineation based on Amino-acid PET (AA-PET) leads to an improvement in progression free survival in patients with recurrent GBM treated with re-irradiation, compared to target volume delineation based on Gadolinium contrast enhanced T1 weighted Magnetic Resonance Imaging (T1Gd-MRI).

 

Inclusion criteria

  • Local recurrence of GBM (WHO grade IV) and either not eligible for tumor resection or with macroscopic residual tumor after resection of recurrent GBM
  • Histological confirmation of GBM at initial or secondary diagnosis
  • Previous radiation therapy of the primary with a maximal total dose 59-60 Gy
  • At least 6 months since the end of pre-irradiation
  • Recurrent tumor visible on AA-PET and T1Gd-MRI with the diameter measuring 1cm to 6cm by either technique
  • Target volume definition possible according to both study arms
  • Start of re-irradiation possible within 2 weeks from FET-PET and MRI
  • Patient's written IC obtained on the day of FET-PET acquisition or latest the day after FET-PET acquisition
  • Legal capacity
  • Karnofsky Performance Score (KPS) > 60%
  • Age ≥18 years (no upper limit of age)
  • Registration

Exclusion criteria

  • No histological confirmation of GBM
  • Recent (≤4 weeks before IC) histological result showing no tumor recurrence
  • No prior radiation treatment to the primary tumor
  • More than 2 previous chemotherapy regimes or previous treatment with Avastin or other molecular targeted therapies
  • Technical impossibility to use MRI or FET-PET for Radiation Therapy (RT)-planning
  • Less than 2 weeks between application of chemotherapy and planned start of re-irradiation
  • Less than 3 weeks between resection of recurrent GBM and planned start of re-irradiation
  • Chemotherapy or molecular targeted therapies planned during re-irradiation
  • Additional chemotherapy or molecular targeted therapy or further surgery planned before diagnosis of further tumor progression after study intervention
  • Female patients of childbearing potential who are pregnant or breast feeding
  • Fertile patients refusing to use safe contraceptive methods during the study
  • Known allergy against the MRI contrast agent Gadolinium or the PET tracer 18F FET or against any of the components

In Kooperation mit

Institut für Strahlenmedizin

Logo der ESTRO

Aktuelles

12.11.2020: Zwei Studentinnen des MSc Radiation Biology erhalten ein Stipendium des Marie-Sklodowska-Curie Fellowship Programme der International Atomic Energy Agency(IAEA): Mehr dazu: Aktuelles


03.11.2020: Kommen Sie in unser Team! - Wir suchen Sie als:

Medizinische Schreibkraft (m/w/d) Sekretärin (m/w/d) im Gesundheitswesen in Voll- oder Teilzeit,
Assistenzarzt (m/w/d) als Physician Scientist (m/w/d),
Verwaltungsangestellten (m/w/d) für die onkologische Ambulanz,
Medizinischen Fachangestellten (m/w/d),
MTRA (m/w/d). Mehr dazu: Stellenausschreibungen


14.10.2020:

Univ.-Prof. Dr. med. Stephanie E. Combs
zu Gast im "alpha-thema Gespräch: Krebsbehandlung heute" bei ARD alpha und abrufbar in der Mediathek.  
Mehr dazu: Aktuelles


02.09.2020: Wir suchen Sie! - Stellenanzeige: MTRA (m/w/d): Mehr dazu: Stellenausschreibungen


01.07.2020: Neues Programm zum ASPO-Symposium über aktuelle Standards und Perspektiven in der Onkologie online:
Information zu COVID-19

Mehr dazu: Download


09.04.2020: Aktuelle Informationen für unsere Patienten zu COVID-19 von Prof. Dr. med. Stephanie E. Combs als PDF-Datei: Download
Information zu COVID-19

 

 



 

Medizinische Schreibkraft (m/w/d) Sekretärin (m/w/d) im Gesundheitswesen in Voll- oder Teilzeit